Aoife Carr Selected Research

Lapatinib (GW572016)

1/2018	Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer.
10/2017	A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib.
7/2017	Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

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Aoife Carr Research Topics

Disease

7	Neoplasms (Cancer) 07/2020 - 07/2017
6	Breast Neoplasms (Breast Cancer) 03/2021 - 11/2016
2	Colorectal Neoplasms (Colorectal Cancer) 12/2023 - 07/2020
1	Adenocarcinoma 06/2023
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2023
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2023
1	Disease Progression 03/2021
1	Stomach Neoplasms (Stomach Cancer) 01/2021
1	Rectal Neoplasms (Rectal Cancer) 07/2020
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2018
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2018
1	Carcinogenesis 01/2018

Drug/Important Bio-Agent (IBA)

6	Trastuzumab (Herceptin)FDA Link 03/2021 - 11/2016
3	copanlisibIBA 03/2021 - 10/2017
3	Lapatinib (GW572016)FDA Link 01/2018 - 07/2017
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2023 - 10/2017
2	DNA (Deoxyribonucleic Acid)IBA 06/2023 - 01/2020
2	Phosphotransferases (Kinase)IBA 03/2021 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2018
2	Carboplatin (JM8)FDA LinkGeneric 01/2018 - 07/2017
2	Docetaxel (Taxotere)FDA Link 01/2018 - 07/2017
1	gedatolisibIBA 12/2023
1	palbociclibIBA 12/2023
1	mirdametinibIBA 12/2023
1	Protein Tyrosine PhosphatasesIBA 06/2023
1	RNA (Ribonucleic Acid)IBA 07/2020
1	Mutant Proteins (Protein, Mutant)IBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	ErbB Receptors (EGF Receptor)IBA 01/2018
1	Epidermal Growth Factor (EGF)IBA 01/2018
1	AfatinibIBA 01/2018
1	FurinIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 10/2017
1	N- (3,4- difluoro- 2- (2- fluoro- 4- iodophenylamino)- 6- methoxyphenyl)- 1- (2,3- dihydroxypropyl)cyclopropane- 1- sulfonamideIBA 10/2017
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2017
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2017
1	human ERBB2 proteinIBA 07/2017
1	Protein Kinases (Protein Kinase)IBA 07/2017
1	tyrosine receptor (receptor, tyrosine)IBA 07/2017

Therapy/Procedure

8	Therapeutics 12/2023 - 07/2017
1	Neoadjuvant Therapy 07/2020